Abstract

Anxiety disorders are among the most common mental health conditions, with a notable rise in the affected population in the past few decades. Such changes have led to an increased prescription of anxiolytics, particularly benzodiazepines. Given that many patients use benzodiazepines alongside other medications, it is crucial to consider the potential interactions that may occur. The aim of this review article is to provide insight into the pharmacokinetic and pharmacodynamic interactions of benzodiazepines with various other drugs, with special emphasis on the role of cytochrome P450 enzymes and the GABA-A receptors. An evaluation of specific drug combinations, their effects on the metabolism and benzodiazepine action, as well as potential clinical implications, can provide valuable insights when it comes to making informed clinical decisions and minimizing the risk of adverse drug reactions.